Job type
TemporaryLocation
MacclesfieldWorking Pattern
Full-timeSpecialism
Research And DevelopmentIndustry
PharmaceuticalsPay
Hourly RateClosing date
31 Dec 2025
AZ requires a senior scientist on an interim basis to work in Macclesfield HQ.
Title :
Senior Scientist
Senior Scientist
Location:
Macclesfield, UK
Macclesfield, UK
Remote/Onsite Requirement:
60-80%% Onsite Minimum (Lab based role) Lab in Vito
60-80%% Onsite Minimum (Lab based role) Lab in Vito
Duration of Contract:
9 Months
9 Months
Days/Hours:
Full Time
Full Time
QDOS Determination:
INSIDE
INSIDE
AstraZeneca is a global, innovation-driven biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to our patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a phenomenal place to work and have a culture that encourages innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity.
Chemical Development:
In Chemical Development we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients. We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop.
We have an open position for a Senior Scientist in our vibrant Particle Engineering community.
As a Senior Scientist, you will be a scientific leader in our growing crystallisation and particle engineering community across Chemical Development. Together with teams of colleagues in other departments and skill areas you will design, develop, optimise and scale-up challenging processes to robustly deliver materials with desired physicochemical attributes. You will also plan and drive improvement projects, use new technologies or modify our ways of working within AstraZeneca or externally with our Contract Development and Manufacturing Organisations (CDMOs).
Key role responsibilities include:
- Contribute to projects focusing on sustainable process development and manufacture of drug substances and provide the link through to Drug Product.
- Provide crystallisation expertise in process development, process scale-up and manufacturability for drug substance and intermediates as an integral part of route development.
- Work collaboratively with colleagues in Drug Product Development to identify and define the required particle properties for downstream processing.
- Drive the Drug Substance control strategy, ensuring processes are fully understood and will robustly deliver consistent drug substance quality and align with Drug Product control strategy.
- Deliver Chemistry Manufacturing and Controls (CMC) content and contributions to regulatory filings throughout the clinical development phase and commercial launch.
- Tackle and provide technical leadership for complex scientific problems.
Essential Requirements:
- A degree and / or PhD in Chemistry or Chemical Engineering.
- Provide support for the development and delivery of intermediates and API particle processes internally & externally.
- Have the ability to work collaboratively with colleagues in Drug Product Development in multi - functional teams to define desired particle properties for formulations, manufacturability and bioavailability.
- Generating, reporting and interpreting high quality data with clear impact to development projects.
- Have the ability to independently represent the department and the Right Particle skill area within multi-functional teams.
- Ability to present information and engage in discussions in multi-disciplinary project teams.
- Effective communication and influencing skills.
- Continuously develop yourself and your colleagues via training and shared learning experiences to improve our efficiency and effectiveness
- Ensuring own work is performed and recorded in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Manufacturing Practice (GMP)
Desirable Skills & Experience:
- Experience of working in the Pharmaceutical or Fine Chemicals Industry.
- Experience in a range of particle/materials characterisation techniques.
- Involvement with working with Contract Development and Manufacturing Organisations (CDMOs).
- Knowledge of particle size reduction unit operations.
- Proficiency with inline Process Analytical Technology (PAT).
- Experience in technology transfer and commercial production.
- Experience of leading and driving improvement projects or new ways of working.
- Collaboration with external partners investigating a new technology or process and implementing these within an industrial setting.
What you need to do now
If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.
If this job isn't quite right for you, but you are looking for a new position, please contact us for a confidential discussion about your career.
For more detailed information, or to view other vacancies with this organisation, please visit our dedicated recruitment website https://webmicrosites.hays.co.uk/web/tempwork_astrazeneca
