Principal Scientist - Non-clinical PKPD

4715529
  • Job type

    Contract
  • Location

    Slough
  • Working Pattern

    Flexible Working,Full-time
  • Specialism

    Research And Development
  • Industry

    Pharmaceuticals
  • Pay

    £38-53 per hour

Principal scientist nonclinical PKPD, global biopharma, 1 year contract, Slough

Your new company
You will be joining a leading global biopharmaceutical company based in Slough who are looking for a Principal Scientist to join their Non-Clinical PK/PD team within Early Clinical Development & Translational Sciences. This contract role (12 months) focusses on the design and execution of non-clinical PK/PD and GLP toxicokinetic (TK) studies, playing a key role in shaping pharmacokinetic and pharmacology strategies.
The successful candidate will contribute to DMPK and PK/PD activities across the drug development continuum, from target identification through to life cycle management, supporting the advancement of innovative therapeutic programmes.

Your new role
  • Lead the design and execution of non-clinical PK/PD and GLP toxicokinetic studies, shaping and driving the overall non-clinical pharmacokinetic/pharmacodynamic (PK/PD) strategy.
  • Contribute to the development of study protocols, including regulatory and exploratory designs, to support the progression of innovative therapeutic candidates.
  • Collaborate cross-functionally with internal and external teams
    to gather requirements, align objectives, and ensure timely delivery of project milestones.
  • Advance drug development efforts by applying deep expertise in drug pharmacology and PK/PD to inform decision-making and optimise candidate selection.
  • Serve as a key liaison between stakeholders, effectively representing departmental interests and ensuring alignment with broader organisational goals.


What you'll need to succeed
  • A PhD or MSc (or equivalent experience) in quantitative pharmacology, pharmacokinetics /pharmacodynamics, DMPK, biology or a related discipline, with strong hands-on experience in PK/PD within a pharmaceutical, biotech, CRO or consultancy environment.
  • Proven expertise in non-clinical PK/PD study design, data analysis, and regulatory reporting, with a strong understanding of pharmacology and disease-related drug mechanisms.
  • Demonstrated hands-on experience in generating and interpreting high-quality preclinical PK/PD data to support drug development.
  • Proficiency in Phoenix WinNonlin for PK/PD analysis is essential; experience with additional modelling and simulation tools such as Berkeley Madonna and/or R is highly desirable.
  • A track record of scientific publications and contributions relevant to PK/PD is considered an asset.


What you'll get in return
The chance to make a significant impact on the company's portfolio and work within a highly experienced team.

What you need to do now
If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.
If this job isn't quite right for you but you are looking for a new position, please contact us for a confidential discussion on your career.

Keywords: Principal, Scientist, Nonclinical, PKPD, Pharmacokinetics, Pharmacodynamics, PK, PD, Toxicokinetics, GLP, Compliance, Phoenix, WinNonlin, Berkeley, Madonna, R, Programming, Quantitative, Pharmacology, DMPK, Drug, Development, Preclinical, Translational, biotech, pharma, Clinical, Bioanalysis, Immunogenicity, Safety, Regulatory

Apply for this job

Talk to Ben Van Zwanenberg, the specialist consultant managing this position

Located in London-City, 5th Floor, 107 Cheapside, Telephone 0203 465 0057
Click here to access our Privacy Policy, which provides detailed information on how we use and protect your personal information, and your rights in relation to this.